Endocrine Abstracts

Introduction: Addison disease is associated with high risk of fractures and low bone mineral density. Causes are complex, including supraphysiologic glucocorticoid replacement therapy and concomitant autoimmune disorders. The aim of our study is to assess the influence of glucorticoid replacement therapy on bone mineral density in patients with Addison disease.Patients and methods: Descriptive and analytical cross- sectional study including 50 patients w...

Introduction: Metabolic syndrome (MS) is responsible for the increased cardiovascular risk in type 2 diabetics, but few studies have looked at the metabolic syndrome in type 1 diabetics. The aim of This study is to evaluate the prevalence of microvascular and macrovascular complications and evaluate the cardiovascular risk among patients with T1DM associated with metabolic syndrome.Materials and Methods: Retrospective study which included 36 type 1 diabe...

Introduction: Mixed connective tissue disease (MCTD), also known as Sharp´s syndrome is a rare autoimmune disease (AD), characterized by the presence of high titers of a distinctive autoantibody: ribonucleoprotein auto-antibody (anti-RNP). It presents with varied overlapping symptoms of different connective tissue disorders which may appear sequentially over time. As other AD, MCTD may be associated with one or more AD, such as autoimmune thyroid disorders (AITD).<p c...

Introduction: Type 1 diabetes mellitus (T1DM) is the result of the autoimmune destruction of beta-cells of the endocrine pancreas, leading to absolute insulin deficiency. The process of this autoimmune destruction occurs in genetically susceptible individuals with positive relevant autoantibodies. T1DM may be associated with other autoimmune diseases (AD) such as autoimmune thyroid disorders (AITD). Patients and methods: It is a descriptive retrospective...

Introduction: Autoimmune hepatitis (AIH) is a generally progressive and chronic liver disease that can occur both in children and adults. Although the cause of AIH is unknown, aberrant auto-reactivity is thought to have a role in its pathogenesis. The diagnosis is based on clinical presentation, biological and histological findings. Like other autoimmune diseases (AD), AIH can be associated with one or more AD either organ-specific or non-organ specific AD. <p class="abste...

Introduction: Cardiothyreosis is the consequence of the effects of excess free thyroid hormones on the vascular wall and myocardium. This complication is the most serious aspect of hyperthyroidism. Rhythm disorders and heart failure are the most frequently noted. The prevalence of coronary insufficiency is lower. The aim of this study is to evaluate the characteristics of coronary insufficiency in patients with hyperthyroidism.Method: This is a retrospec...

Objective: To describe the clinical and biological presentation of acute pancreatitis (AP) and diabetic ketoacidosis (DKA) in type 1 diabetes (T1D).Patients and Methods: A retrospective descriptive study of 10 T1DM patients with simultaneous DKA and AP.Results: The mean age at diagnosis of T1DM was 19.7&pm;9.3 years with a female predominance (60%). T1DM was frequently inaugurated by a cardinal syndrome (50%) or spontaneous DKA (20...

Objective: To assess the prevalence of obesity and metabolic disorders in patients with non-functional pituitary adenomas (NFPA)Patients and methods: A retrospective descriptive study of 35 patients followed for NFPA between 2000 and 2022. Metabolic syndrome was established according to the National Cholesterol Education Program Adult Treatment Panel III criteria.Results: The mean age was 52.1±11.4 years, with a male predomina...

Objective: To describe the radiological features of non-functioning pituitary adenomas (NFPA) at diagnosis.Patients and methods: A retrospective descriptive study of 35 patients followed for NFPA between 2000 and 2022. A pituitary magnetic resonance imaging (MRI) scan was performed in all patients.Results: The mean age was 52.1±11.4 years with a male predominance (61.3%). Pituitary tumor syndrome was the main reason for consul...

Background and Aim: Non-functioning pituitary adenoma (NFPA) is the second most common subtype of pituitary adenomas. This study aims to detail the clinical and biological particularities of NFPA in the Tunisian population.Patients and Methods: A retrospective descriptive study of 35 patients followed for NFPA was conducted between 2000 and 2022 at the endocrinology Department of Hedi Chaker University Hospital, Sfax, Tunisia.Resul...